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KMID : 0364219900330040493
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Korean Journal of Zoology
1990 Volume.33 No. 4 p.493 ~ p.498
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Effect of 6-Aminonicotinamide on the Levels of Some Metabolites and Related Enzymes in Rabbit Serum
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Park In-Kook
Lee Chul-Seung
Lee Seung-Hoon
Song Yoon-Kyung
Shin Sook
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Abstract
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The effects of an antimetabolite, 6-aminonicotinamide (6-AN) on the levels of enzymes and metabolites in rabbit serum were investigated. The intraperitoneal administration of 6-AN (multiple doses of l5mg/kg body weight) gave tise to a remarkable increase in glucose and cholesterol levels but did not exert any appreciable influence on the concentration of albumin and total protein. Alkaline phosphatase activity was significantly reduced by administration of 6-AN, whereas creatine phophokinase, serum glutamic oxaloacetate transaminase and serum glutamic pyruvate transaminase activities were matkedly enhanced. Nevettheless, the levels of Ca, P, Na, K, Cl and Co were not affeded to any extent by 6-AN.
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KEYWORD
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6-Aminonicotinamide, Enzymes, Metabolites
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